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HGH: Myth and Reality
By: Michele Ferrari
Published: 14 Apr 2011



The belief that the Human Growth Hormone (HGH) enhances athletic performances comes from the observation that it allows an increase in body lean mass and a decrease in body fat %, even in healthy subjects.

A recent study (Ann Intern Med 2010; 152:568-577) administered 2mg of HGH per day, subcutaneously for 8 weeks, to a group of amateur athletes all aged below 40, eventually comparing the results in double blind to a control group.

The pharmacological treatment effectively reduced fat mass by an average of 2.1kg (equal to 3% of body weight), increased the lean mass by an average of 3.3kg (equal to 4.7% of body weight), therefore adding 1.2kg in body weight.

There was no apparent improvement in the measurement of VO2max, in maximal isometric strength and in standing high jump efforts, while the capacity of sprinting for a maximal effort of 30” on a cycloergometer resulted improved by approximately 4%.

The Authors therefore hypothesize that the treatment with HGH enhances the anaerobic lactacid metabolism.

Observations:

- the group of athletes under examination is of mediocre level: VO2max = 3.2 L/min, equal to 45.7 ml/kg/min, with little training and an average body fat % = 23.2%

- the dose of HGH that was subjected was not so modest (2mg correspond to 6 IU), equal to 6–8 times the average daily production in a healthy young adult.
In fact, several collateral effects were reported among the subjects: muscular and articular pain, strong perspiration, paresthesia

- the cycloergometer test was nonspecific for the majority of the participants, who were not cyclists. The Authors observed that an improvement of 4% could correspond to 0.4 seconds in a 100m sprint or to 1.2 seconds in a 50m swimming competition…
In order to verify such claim, it would be opportune to evaluate top-level athletes performing their own specific sport: frankly such improvements are not presumable

- the reduction in fat mass pointed out by the study can be easily obtained through adequate nutrition, especially on a group of athletes with a fat percentage above 20%; similarly, an increase in lean mass can occur through proper training and a diet with sufficient protein intake.

A careful reader of 53x12.com (CM, United States) wondered why the use of HGH is so widespread in sports, if its effects on performance are so dubious.
I shall try to answer:

- the (erroneous) belief that HGH is not traceable in antidoping tests surely plays a major role in the decision to take such substance

- HGH is a very powerful hormone, capable of altering metabolism and likely inducing certain feelings (of strength, muscle “fullness”) in the subjects, although these are not guarantee of any increase in performances.
Many times the user actually reports increased internal frictions, with the effect of a “blocked” sensation; specific to cycling, this may induce to using low cadences, pushing long gears, consequently overloading muscles and tendons.

- if athletes using it notice any improvement in their performances, this is due to a placebo effect supported by subjective “feelings” and a stronger determination of the athlete with regard to training, nutrition, lifestyle, in the belief that he/she’s adopting the best strategy in order to get the best results.

More from Other :
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Rominger's Hour 17 Oct 2003
Every Athlete is Unique 26 Mar 2004
My Own Records 12 Sep 2004
Training & Hormones 20 Sep 2004
VO2max - Useful? 12 Nov 2004
Lactic Acid: Good or Bad? 22 Dec 2004
Running for the Cyclist 31 Dec 2004
The Anaerobic Threshold 13 Jan 2005
Pulmonary Breathing 6 Sep 2005
More on Altitude and Hypoxia 3 Nov 2006
Fatigue: peripheral or central? 16 Nov 2006
Measuring the anaerobic threshold 2 Dec 2006
Iron Metabolism 13 Sep 2007
Variability of Hematic Parameters 8 Nov 2007
More on Hematic Parameters and Altitude 17 Nov 2007
Biological Passport & Other 2 Dec 2008
Where are the Stage Races going? 13 Dec 2008
More on the Biologic Passport 23 Jun 2009
WADA and Biologic Passport 31 Dec 2009
The Pechstein Case 17 Apr 2010
The Biologic Passport - UCI version 30 Jul 2010
Hb and OFFs: individual variance 26 Oct 2010
Specialization in cycling and complete riders 21 Nov 2010
Thoughts and Words 30 Nov 2010
Graphic Representations 3 Dec 2010
Good Ones and Bad Ones 3 Dec 2010
True or False, pt. 2 4 Dec 2010
Independent Experts: reliable? 7 Dec 2010
Something to Say 15 Dec 2010
Three Questions, Three Answers 24 Dec 2010
Interesting Reading 2 Feb 2011
UCI's Mess 18 Feb 2011
UCI's Ambush Complacency 23 Mar 2011
UCI and Rules 7 Apr 2011
HGH: Myth and Reality 14 Apr 2011
Doping Trials: the Facts 2 May 2011
Doping Trials: the Facts - Pt. 2 8 May 2011
Suspicious Test & Test Suspicions 5 Jun 2011
Castles Made of Sand 22 Sep 2011
Mentheour: a Concert of Lies 5 Oct 2011
Climbs and Time Trials 13 Oct 2011
Measuring the Hb Mass 10 Nov 2011
Can Lance win in Kona? 21 Feb 2012
Giving Blood Is Good For The Brain 21 Jun 2012
Incredible Biological Passport 28 Jun 2012
USADA: Arrogant Execution 12 Jul 2012
USADA: the Farce Continues 13 Jul 2012
The Schwazer Case 8 Aug 2012
The Bad Science 22 Sep 2012
Reply to Parisotto's Rebuttal 27 Sep 2012
Parisotto - Part III 29 Sep 2012
Parisotto - Final Response 10 Oct 2012
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